Subject:
Invitation to the “100 Years of Metachromatic Leukodystrophy” Symposium – 14–15 November 2025
Dear Colleagues,
We are delighted to invite you to our international symposium “100 Years of Metachromatic Leukodystrophy: From Discovery to Cure”,
taking place on 14–15 November 2025 in Tübingen, Germany.
This special event will commemorate a century since the first description of MLD in Tübingen, bringing together experts from across Europe to discuss past achievements, current management strategies, and future perspectives, including newborn screening and gene therapy.
Prof. Dr. Samuel Gröschel,
Prof. Dr Hendrick Rosewich
Dates and preliminary Program
14 November 2025 | 14:00–18:45 – Scientific Talks and Discussion
Session I: A Century of Progress in MLD
Ingeborg Krägeloh-Mann – Milestones in MLD Research
Nicole Wolf – Understanding the Disease: Pathomechanisms and Histology
Les Martin, Michael Scholz, Hanka Dekker – Patient Perspective: Caring and Advocacy
Carola Reinhard, Marije Asbreuk – Collaboration on MLD: ERN-RND and MLD Initiative
Session II: Transforming MLD Care: From Trials to Comprehensive Management
Francesca Fumagalli – Advancing Therapies
Caroline Sevin – Hematopoietic Stem Cell Transplantation in MLD
Simon Jones – Future Directions in the Treatment of Lysosomal Disorders
Laura Adang – Patient-Centric Trial Design
Annemieke Buizer – Disease Management in Advanced MLD
Session III: MLD Across the Lifespan: Diagnosis, Monitoring, and Biomarkers
Christiane Kehrer – Survival in MLD: End-of-Life Care
Lucia Laugwitz, Xinying Hong – Biomarkers and Early Diagnosis: Newborn Screening and Prediction
Pascal Martin – MRI for Disease Monitoring
Shanice Beerepoot – Assessing Peripheral Neuropathy
Fanny Mochel – Adult-Onset MLD: Clinical Challenges
From 19:15 – Dinner and Social Gathering
15 November 2025 | 09:00–12:30 – Parallel Workshops
Understand key phases of the patient journey
Identify unmet needs and psychosocial support structures
Improve communication and integration of patient perspectives
early MRI patterns and clinical clinical signs
diagnostic algorithms and early biochemical/genetic testing
Longitudinal disease monitoring: clinical scores, imaging, biomarkers
Coordination of care and family support networks
Best practices in supportive and palliative care
Role of HSCT and gene therapy in clinical management
Registration
Please register by 30th Sept 2025 using this link: https://eveeno.com/182090309. Participation is free but spaces are limited.
Accommodation
A limited number of rooms are reserved in nearby hotels (see list below). Please book early!
Contact
Please feel free to contact us: 100yearsMLD@med.uni-tuebingen.de
We look forward to welcoming you to Tübingen for this important gathering to shape the future of MLD care and research.
Hotel Krone Tübingen
Uhlandstr. 1, 72072 Tübingen
Tel: +49 7071 1331-0 | Email: reservierung@krone-tuebingen.de
Double Room: €206 / night
Includes breakfast buffet, spa & fitness access, Wi-Fi, VAT
Parking: €20/night (cannot be reserved)
Book by email mentioning “Kinderklinik Frau Steinhilber”
GIZ Tübingen
Hoppe-Seyler-Str. 6, 72076 Tübingen
Tel: +49 7071 4101-0 | Email: info@gzt-tuebingen.de
Double Room: €137 / night
Single Use: €132 / night
Single Room: €114 / night
Breakfast: €14 / person / night (optional)
Book with keyword: “100 years MLD”
Hotel Domizil Tübingen
Wöhrdstr. 5–9, 72072 Tübingen
Tel: +49 7071 139-0 | Email: info@hotel-domizil.de
Double Room: €184 / night
Single Use: €148 / night
Includes breakfast
Room block available until 26 Sept 2025
Book with keyword: “100 years MLD”
