Registration
Info
Advances in genomics have many benefits for precision medicine. Emerging technologies such as Next Generation Sequencing (NGS) are improving patient health, enabling earlier and more accurate diagnosis, helping to target therapies and reducing the overall cost of care (precision medicine). NGS offers ultra-high throughput, scalability and speed. However, the quality, comparability and standardization of genomic profiling varies significantly, and the development of reference measurement systems and standards is still in their infancy stage. The workshop aims to bring together experts and stakeholders to identify the metrological-related questions and approaches that could contribute to the standardization and harmonization of NGS results. Standardization in NGS provides a first basis for further work on the implementation of NGS in important areas such as clinical diagnostics, where reliable results and rapid processing are essential. The workshop will also support the quality assurance, standardization, and reproducibility of sequence data.
Key metrological questions related to NGS:
1. How can metrology contribute to the quality assurance, comparability and reproducibility of NGS results?
2. Which biochemical and/or biomedical properties should be measured quantitatively, and to what level of precision?
3. How can metrology contribute to the development of clear guidelines and instructions for NGS workflows needed to verify the quality of data and procedures?
4. How can metrology be integrated into NGS regulatory processes?
5. How can metrology overcome the challenges of sample commutability with different metrics?
Date: 28.September.2023
Venue: PTB Berlin, Charlottenburg, Hermann von Helmholtz Lecture Hall
Early bird registrtion fee until 05.06.2023.
Agenda:
10:00-10:15 Welcome
10:15-10:40 „Aspects of quality assurance in Next Generation Sequencing“ Prof. Dr. med. Parviz Ahmad-Nejad, Helios Universitätsklinikum Wuppertal, Germany (Keynote speaker)
10:40-11:05 „Applying metagenomics for real time outbreak investigation“ Prof. Jacob Moran-Gilad, Ben-Gurion University of the Negev, Israel.
11:05-11:30 „Sequins - dPCR-traceable DNA standards for quantitative metagenomics” Dr. Kai Stoelting, METAS, Switzerland.
11:30-11:45 Coffee break
11:45-12:10 „NGS Technologies and Applications – a genomics technology platform perspective” Dr. Janine Allmüller, Berlin Institute of Health at Charité– Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine, Germany
12:10-12:35 „Development of metrology to support genomic NGS profiling for early cancer detection and precision medicine (GenomeMET)” Dr. Carole Foy, NML (LGC), UK
12:35-13:00 „Navigating analytical and regulatory hurdles for the clinical implementation of ultrasensitive sequencing in precision oncology“
Stefan Filges, Simsen Diagnostics AB, Gothenburg, Sweden
13:00-14:00 Lunch break
14:00-14:25 „The complementary nature of droplet digital PCR and Next Generation Sequencing“ Dr. Adam Corner, Bio Rad, UK
14:25-14:50 „Understanding sources of error in NGS with Genome in a Bottle benchmarks” Dr. Justin Zook, NIST, USA
14:50-15:15 „Measurement uncertainty in clinical NGS”
Dr. Nathaniel Storey, NHS, UK
15:15-15:45 Final discussion
Event location
Hermann von Helmholtz BauHvH Hörsaal (Lecture Hall)
Abbestraße 2-12
10587 PTB Berlin
Deutschland
Coordinates (lat, long):
52.515961, 13.318785
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Notes
Arrival by airplane
The former airport TXL (Tegel) is now closed. You will arrive at BER Brandenburg (south of Berlin).
Taxi
Transport by taxi from Terminal 1-2 to PTB (Abbestr. 2-12, 10587 Berlin) nominally takes 37 minutes. However, traffic jams are to be expected. A travel time around 1 hour or more is realistic. Price per direction is about 80 EUR.
Public transport
There are different options to go by public transport from BER Airport Terminal 5 or Terminal 1-2 to PTB (bus stop Marchstr. 10587 Berlin). You can check at https://www.vbb.de/en/
We suggest taking S-Bahn S9 form BER to "Zoologischer Garten" (20 stops), and then take bus 245 or M45 to Marchstr. (3 stops). Travel time to PTB will be about 1h25
Arrival by train
If you arrive at "Bahnhof Lichtenberg" take S-Bahn S5 or S7 to "Zoologischer Garten" (12 stops). If you arrive at "Hauptbahnhof" take S-Bahn S3, S5, S7 or S9 to Zoologischer Garten" (3 stops). Next take bus 245 or M45 to Marchstr. (3 stops)
